Surveys indicate that roughly 40–50% of HIV cases progressed to AIDS within the first year of diagnosis largely due to late diagnosis ( 3, 4). Moreover, WB tests can only be performed by lab-professionals, which greatly restrict the accessibility of HIV testing. It usually takes up to 7–14 days to get the result and costs a lot ( 1, 2). Western blot (WB) is regarded as the gold standard for a definitive confirmatory test for HIV infection. Blood-based rapid HIV tests have comparable sensitivity and specificity to WB for HIV early therapy. Regarding two-step serial RTs, the pooled sensitivity, specificity area under SROC, and DOR derived from eight studies were 0.998 (95% CI, 0.991–1.000), 0.998 (95% CI, 0.994–0.999), and 1.00 (95% CI 0.99–1.00) compared with the WB assay, respectively.Ĭonclusion: Our meta-analysis results may provide evidenced-based support for substituting RT for WB. Results: Twenty articles involving 27,343 fresh specimens for rapid HIV tests were included in the meta-analysis. A meta-analysis was performed to quantitatively evaluate the diagnostic performance of rapid HIV tests compared with the WB assay in terms of pooled sensitivity, specificity, area under summary receiver operating characteristic (SROC) curve, and diagnostic odds ratio (DOR). Methods: PubMed and Web of Science were searched for publications on rapid HIV tests using blood specimen. This study aims to compare the diagnostic performance of rapid HIV tests compared with WB. However, this rapid testing strategy has not been promoted worldwide due to inadequate research evaluating the effectiveness of rapid tests (RTs) as an alternative confirmatory HIV test for WB. WHO recommends blood-based rapid diagnosis to achieve same-day test and treatment. However, it requires technical expertise and is quite time-consuming. 7Zunyi Medical University, Zunyi, Chinaīackground: Western blot (WB) assay is considered the gold standard test for HIV infection confirmation. 6Department of Infectious Diseases, Chongqing Public Health Medical Center, Chongqing, China.5School of Biomedical Engineering, Capital Medical University, Beijing, China.4AIDS Healthcare Foundation, Beijing, China.3Department of Information Technology, Peking Union Medical College Hospital, Beijing, China.2Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing, China.1Center for Infectious Diseases, Beijing You’an Hospital, Capital Medical University, Beijing, China.
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